The components that can generate noise in the PC are the fans (there could be several), CD or DVD drive, Floppy drive, hard drive and power supply. You should start by ejecting any disks that might be inside of any of the drives, such as the floppy, Zip drive or CD drive. If there are no disks, and no activity lights on those devices, then it is likely one of the following:
CPU FAN NOISES
You have at least one, but probably as many as three or four fans inside of your computer. You are guaranteed to have a fan in the Power supply. The power supply is at the back of the computer and has an exhaust fan. Some power supplies have another fan inside that draws air upward from the CPU so the exhaust fan can pull the heat out of the case.
You probably also have a fan on the CPU. The CPU fan will rest atop a metal heat sink. This fan is responsible for pulling the heat away from the CPU to keep it cool.
There could be intake fans in the front of the case and exhaust fans going out the back.
There could also be a fan on the video card GPU, which is similar to the CPU fan, but smaller.
A couple of things can happen with fans. They can simply be dirty and need to be blown out with compressed air. Or the bearings in them are starting to fail. If it is the latter, you will need to replace the fan. If the case is open, you can usually quickly pinpoint the fan that is causing the issue. If compressed air does not fix a noisy power supply fan, replace the entire power supply immediately.
The power supply can have a couple of noises. It could have a bad or dirty fan as described above, or it can be making an electrical humming noise. If blowing the fan out does not help, or if you do hear the electrical hum, unplug the computer and replace the power supply immediately.
It’s not unusual for the hard drive to churn and hum as it works. If you notice loud noises above that, a few things can be happening. There could be physical defects on the platters, causing the high-speed head to bounce. It could have a bad actuator arm or read / write head. Both of these necessitate an immediate replacement of the drive. Or it could just be struggling to read and write due to a lack of space or maintenance. Check the remaining capacity and remove anything you can if the space is low. Then defrag the drive by going to Start>All Programs>Accessories>System Tools>Drive Defragmenter.
You might also want to run the Disk Checking Utility. This will scan for physical defects on the drive and mark them as non-usable. To do this, right-click the C Drive in My Computer and select Properties. Under the Tools tab, click the Check Now button and have it scan and fix any errors it finds.
In conclusion, the power supply is not serviceable. Any noise coming from there is bad news and the power supply should be replace. All other fans–even the video card fan–can be replaced, if necessary. If the hard drive is making noises, back up all data, remove what you can and run the disk defragmenter and disk checking utility.